Varicella zoster vaccines and their implications for development of HSV vaccines.

Abstract

Live attenuated vaccines to prevent varicella and zoster have been available in the US for the past 17 years, with a resultant dramatic decrease in varicella incidence and a predicted future decrease in the incidence of zoster. The pathogenesis and immune responses to varicella zoster virus (VZV) as well as the safety and effectiveness of VZV vaccines are reviewed. The lack of sterilizing immunity provided by VZV vaccines has not prevented them from being safe and effective. Virological and pathological information concerning parallels and differences between VZV and herpes simplex virus (HSV) are highlighted. Although VZV and HSV are distinct pathogens, they appear to have similarities in target organs and immunity that provide an expectation of a high likelihood for the success of vaccination against HSV, and predicted to be similar to that of VZV.

• Authors: Anne A Gershon
• Journal: Virology (Virology) Vol. 435 Issue 1 Pg. 29-36 (Jan 05 2013) ISSN: 1096-0341 [Electronic] United States
• PMID: 23217613 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Herpes Simplex Virus Vaccines
• Herpes Zoster Vaccine
• Vaccines, Attenuated

Topics

• Chickenpox (immunology)
• Child
• Child, Preschool
• Herpes Simplex (immunology, mortality, prevention & control, virology)
• Herpes Simplex Virus Vaccines (administration & dosage, immunology)
• Herpes Zoster (immunology, mortality, prevention & control, virology)
• Herpes Zoster Vaccine (administration & dosage, immunology)
• Herpesvirus 3, Human (immunology)
• Humans
• Immunity, Cellular (drug effects)
• Middle Aged
• Simplexvirus (immunology)
• Survival Rate
• Vaccination
• Vaccines, Attenuated