Abstract | BACKGROUND: RESULTS: The ventricular dilatation were evaluated by MRI at 1-week post drugs treated, while GFAP and Iba-1were detected by RT-PCR, Immunohistochemistry and Western blot. The expression of GFAP and Iba-1 was significantly higher in hydrocephalic group compared with saline control group (p < 0.05). Minocycline treatment of hydrocephalic animals reduced the expression of GFAP and Iba-1 significantly (p < 0.05). Likewise, the severity of ventricular dilatation is lower in minocycline treated hydrocephalic animals compared with the no minocycline group (p < 0.05). CONCLUSION:
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Authors | Hao Xu, Guowei Tan, Shaolin Zhang, Hongwei Zhu, Feng Liu, Caiquan Huang, Feifei Zhang, Zhanxiang Wang |
Journal | BMC neuroscience
(BMC Neurosci)
Vol. 13
Pg. 148
(Dec 05 2012)
ISSN: 1471-2202 [Electronic] England |
PMID | 23217034
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aif1 protein, rat
- Calcium-Binding Proteins
- Glial Fibrillary Acidic Protein
- Microfilament Proteins
- Minocycline
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Topics |
- Analysis of Variance
- Animals
- Calcium-Binding Proteins
(genetics, metabolism)
- Cerebral Ventricles
(drug effects, pathology)
- Disease Models, Animal
- Double-Blind Method
- Gene Expression Regulation
(drug effects)
- Glial Fibrillary Acidic Protein
(genetics, metabolism)
- Gliosis
(drug therapy, etiology, metabolism, pathology)
- Hydrocephalus
(complications, drug therapy, mortality, pathology)
- Magnetic Resonance Imaging
- Male
- Microfilament Proteins
(genetics, metabolism)
- Minocycline
(therapeutic use)
- Rats
- Rats, Sprague-Dawley
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