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Minocycline reduces reactive gliosis in the rat model of hydrocephalus.

AbstractBACKGROUND:
Reactive gliosis had been implicated in injury and recovery patterns associated with hydrocephalus. Our aim is to determine the efficacy of minocycline, an antibiotic known for its anti-inflammatory properties, to reduce reactive gliosis and inhibit the development of hydrocephalus.
RESULTS:
The ventricular dilatation were evaluated by MRI at 1-week post drugs treated, while GFAP and Iba-1were detected by RT-PCR, Immunohistochemistry and Western blot. The expression of GFAP and Iba-1 was significantly higher in hydrocephalic group compared with saline control group (p < 0.05). Minocycline treatment of hydrocephalic animals reduced the expression of GFAP and Iba-1 significantly (p < 0.05). Likewise, the severity of ventricular dilatation is lower in minocycline treated hydrocephalic animals compared with the no minocycline group (p < 0.05).
CONCLUSION:
Minocycline treatment is effective in reducing the gliosis and delaying the development of hydrocephalus with prospective to be the auxiliary therapeutic method of hydrocephalus.
AuthorsHao Xu, Guowei Tan, Shaolin Zhang, Hongwei Zhu, Feng Liu, Caiquan Huang, Feifei Zhang, Zhanxiang Wang
JournalBMC neuroscience (BMC Neurosci) Vol. 13 Pg. 148 (Dec 05 2012) ISSN: 1471-2202 [Electronic] England
PMID23217034 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Aif1 protein, rat
  • Calcium-Binding Proteins
  • Glial Fibrillary Acidic Protein
  • Microfilament Proteins
  • Minocycline
Topics
  • Analysis of Variance
  • Animals
  • Calcium-Binding Proteins (genetics, metabolism)
  • Cerebral Ventricles (drug effects, pathology)
  • Disease Models, Animal
  • Double-Blind Method
  • Gene Expression Regulation (drug effects)
  • Glial Fibrillary Acidic Protein (genetics, metabolism)
  • Gliosis (drug therapy, etiology, metabolism, pathology)
  • Hydrocephalus (complications, drug therapy, mortality, pathology)
  • Magnetic Resonance Imaging
  • Male
  • Microfilament Proteins (genetics, metabolism)
  • Minocycline (therapeutic use)
  • Rats
  • Rats, Sprague-Dawley

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