YAP-Hippo signalling downstream of leukemia inhibitory factor receptor: implications for breast cancer.

Abstract

The proto-oncogenes YAP and TAZ have previously gained much attention as downstream effectors of Hippo tumour suppressor signalling. While the regulation of YAP/TAZ by MST/LATS kinases is reasonably well understood, the nature of factors functioning upstream of MST/LATS is yet to be elucidated in detail. A recent paper by Ma and co-workers defines a novel role for leukemia inhibitory factor receptor (LIFR) signalling upstream of the Hippo-YAP pathway in breast cancer metastasis. Moreover, a whole genome in vivo RNA interference screen by Lippmann and colleagues identified LIFR as a breast tumour suppressor. Here, we discuss the implications of these studies for breast cancer research and treatment.

• Authors: Alexander Hergovich
• Journal: Breast cancer research : BCR (Breast Cancer Res) Vol. 14 Issue 6 Pg. 326 (Dec 05 2012) ISSN: 1465-542X [Electronic] England
• PMID: 23216692 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adaptor Proteins, Signal Transducing
• Phosphoproteins
• Receptors, OSM-LIF
• Transcription Factors
• YAP-Signaling Proteins
• YAP1 protein, human
• Acyltransferases
• TAFAZZIN protein, human
• LATS1 protein, human
• Protein Serine-Threonine Kinases
• MAP Kinase Kinase Kinases
• MAP3K10 protein, human

Topics

• Acyltransferases
• Adaptor Proteins, Signal Transducing (genetics)
• Breast Neoplasms (genetics)
• Female
• Genes, Tumor Suppressor
• Hippo Signaling Pathway
• Humans
• MAP Kinase Kinase Kinases (metabolism)
• Phosphoproteins (genetics)
• Protein Serine-Threonine Kinases (genetics, metabolism)
• RNA Interference
• Receptors, OSM-LIF (genetics)
• Signal Transduction (genetics)
• Transcription Factors (genetics)
• YAP-Signaling Proteins