HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Caffeic acid phenethyl ester alleviates mesenteric ischemia/reperfusion injury.

AbstractPURPOSE:
We aimed to investigate the effects of caffeic acid phenethyl ester (CAPE) on intestinal mucosal injury induced by superior mesenteric occlusion.
METHODS:
This experimental study was conducted on 48 male Wistar-albino rats. The animals were randomly allocated into four groups: (i) Sham-operated group, laparotomy without intestinal ischemia/reperfusion (IR) injury (n = 12); (ii) Sham + CAPE group, identical to group 1 except for CAPE treatment (10 μmol/kg, intravenously) (n = 12); (iii) Intestinal IR group, 60 min of superior mesenteric ischemia followed by 3 hr of reperfusion (n = 12); and (iv) (IR + CAPE)-treated group, 10 μmol/kg injection of CAPE intravenously 30 min before the reperfusion period (n = 12). We evaluated the degree of intestinal mucosal injury on a grading scale, histopathologically, and by measuring oxidative stress markers and antioxidant parameters, biochemically. Intestinal edema was estimated by using wet/dry weight ratios. The plasma proinflammatory cytokine levels were measured. Animal survival was observed up to one week.
RESULTS:
Intestinal mucosal injury scores were significantly decreased with CAPE administration (p < .05). CAPE treatment significantly reduced oxidative stress markers in the intestinal tissues (p < .05) and the plasma proinflammatory cytokine levels (p < .05), and significantly increased antioxidant parameters in the intestinal tissues (p < .05). Intestinal edema was significantly alleviated by CAPE treatment (p < .05). The survival rates of CAPE-treated IR animals were significantly higher than IR-subjected rats (p < .05).
CONCLUSION:
This study clearly showed that CAPE treatment significantly alleviated the intestinal mucosal injury caused by superior mesenteric ischemia/reperfusion. Further clinical studies are required to clarify whether CAPE has a useful role in reperfusion injury during particular surgeries in which IR-induced organ injury occurs.
AuthorsZafer Teke, Erdal Birol Bostanci, Cigdem Yenisey, Mustafa Sacar, Nilufer Genc Simsek, Musa Akoglu
JournalJournal of investigative surgery : the official journal of the Academy of Surgical Research (J Invest Surg) Vol. 25 Issue 6 Pg. 354-65 (Dec 2012) ISSN: 1521-0553 [Electronic] United States
PMID23215792 (Publication Type: Journal Article)
Chemical References
  • Antioxidants
  • Caffeic Acids
  • Cytokines
  • Nitrates
  • Plant Extracts
  • Malondialdehyde
  • Peroxidase
  • Glutathione Peroxidase
  • Xanthine Oxidase
  • caffeic acid phenethyl ester
  • Phenylethyl Alcohol
Topics
  • Animals
  • Antioxidants (pharmacology, therapeutic use)
  • Caffeic Acids (pharmacology, therapeutic use)
  • Cytokines (blood)
  • Glutathione Peroxidase (metabolism)
  • Intestine, Small (blood supply, drug effects, metabolism)
  • Male
  • Malondialdehyde (metabolism)
  • Models, Animal
  • Nitrates (metabolism)
  • Oxidative Stress (drug effects)
  • Peroxidase (metabolism)
  • Phenylethyl Alcohol (analogs & derivatives, pharmacology, therapeutic use)
  • Plant Bark
  • Plant Extracts (pharmacology, therapeutic use)
  • Rats
  • Rats, Wistar
  • Regional Blood Flow (drug effects)
  • Reperfusion Injury (metabolism, prevention & control)
  • Xanthine Oxidase (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: