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Regulation of metabolism of retinol-binding protein by vitamin A status in children with biliary atresia.

Abstract
Regulation of retinol-binding protein (RBP) by vitamin A status was studied in 43 children; 25 had biliary atresia and vitamin A deficiency, 15 had biliary atresia treated by vitamin A, and 9 control children had normal liver and vitamin A status. Vitamin A and RBP were assayed and the two forms of RBP, holo-RBP and apo-RBP, were separated in both liver and plasma. No difference in liver RBP concentrations was found between the three groups; apo-RBP was the most abundant form. Plasma RBP concentrations and the ratio of retinol to RBP were lower for vitamin A-deficient than for vitamin A-treated children. Two models could be proposed: 1) a preferential secretion of holo-RBP with variations in RBP catabolism or synthesis in vitamin A-deficient liver and 2) a continuous secretion of RBP by the liver with a rapid clearance of plasma apo-RBP in vitamin A deficiency.
AuthorsM S Mourey, G Siegenthaler, O Amédée-Manesme
JournalThe American journal of clinical nutrition (Am J Clin Nutr) Vol. 51 Issue 4 Pg. 638-43 (Apr 1990) ISSN: 0002-9165 [Print] United States
PMID2321569 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Retinol-Binding Proteins
  • Retinol-Binding Proteins, Plasma
  • Vitamin A
Topics
  • Biliary Atresia (complications, metabolism)
  • Cholestasis (complications, metabolism)
  • Electrophoresis, Polyacrylamide Gel
  • Female
  • Humans
  • Immunoblotting
  • Infant
  • Infant, Newborn
  • Liver (metabolism)
  • Male
  • Nutritional Status (physiology)
  • Retinol-Binding Proteins (metabolism)
  • Retinol-Binding Proteins, Plasma
  • Vitamin A (blood, therapeutic use)
  • Vitamin A Deficiency (complications, drug therapy, metabolism)

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