Abstract |
Regulation of retinol-binding protein (RBP) by vitamin A status was studied in 43 children; 25 had biliary atresia and vitamin A deficiency, 15 had biliary atresia treated by vitamin A, and 9 control children had normal liver and vitamin A status. Vitamin A and RBP were assayed and the two forms of RBP, holo-RBP and apo-RBP, were separated in both liver and plasma. No difference in liver RBP concentrations was found between the three groups; apo-RBP was the most abundant form. Plasma RBP concentrations and the ratio of retinol to RBP were lower for vitamin A-deficient than for vitamin A-treated children. Two models could be proposed: 1) a preferential secretion of holo-RBP with variations in RBP catabolism or synthesis in vitamin A-deficient liver and 2) a continuous secretion of RBP by the liver with a rapid clearance of plasma apo-RBP in vitamin A deficiency.
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Authors | M S Mourey, G Siegenthaler, O Amédée-Manesme |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 51
Issue 4
Pg. 638-43
(Apr 1990)
ISSN: 0002-9165 [Print] United States |
PMID | 2321569
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Retinol-Binding Proteins
- Retinol-Binding Proteins, Plasma
- Vitamin A
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Topics |
- Biliary Atresia
(complications, metabolism)
- Cholestasis
(complications, metabolism)
- Electrophoresis, Polyacrylamide Gel
- Female
- Humans
- Immunoblotting
- Infant
- Infant, Newborn
- Liver
(metabolism)
- Male
- Nutritional Status
(physiology)
- Retinol-Binding Proteins
(metabolism)
- Retinol-Binding Proteins, Plasma
- Vitamin A
(blood, therapeutic use)
- Vitamin A Deficiency
(complications, drug therapy, metabolism)
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