Biodistribution and pharmacokinetics of S-35-labeled 5-thio-D-glucose in hamsters bearing pancreatic tumors.

Abstract

5-thio-D-glucose (5-TDG) exerts profound effects on rapidly metabolizing tissues. We have used liquid scintillation counting to study the tissue distribution and pharmacokinetics of S-35-labeled 5-TDG in hamster models of pancreatic tumors. In the normal hamster, initial uptake of S-35 activity into kidney, liver, and blood was high, but rapidly decreased with time. The pancreatic uptake (% dose/g) never exceeded 0.75%. This level occurred only at the earliest times after administration. Uptake in all three tumor models exceeded that in pancreatic tissue within 15 min of injection. The highest tumor-to-pancreas ratio was seen in the duct-tumor model, which also exhibited the most favorable tumor-to-tissue ratio when compared with kidney, liver and muscle. Favorable ratios were most pronounced at 6 and 24 hr after injection. These studies provide impetus for the use of 5-TDG as a model compound for the synthesis of potentially useful agents for clinical detection of pancreatic tumors.

• Authors: A M Markoe, V R Risch, N D Heindel, J Emrich, W Lippincott, T Honda, L W Brady
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 20 Issue 7 Pg. 753-60 (Jul 1979) ISSN: 0161-5505 [Print] United States
• PMID: 232149 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Sulfur Radioisotopes
• 5-thio-D-glucose
• Glucose

Topics

• Adenocarcinoma (metabolism)
• Adenoma, Islet Cell (metabolism)
• Animals
• Cricetinae
• Glucose (analogs & derivatives, metabolism)
• Kinetics
• Male
• Mesocricetus
• Neoplasms, Experimental (metabolism)
• Pancreatic Ducts
• Pancreatic Neoplasms (metabolism)
• Sulfur Radioisotopes
• Tissue Distribution