Abstract | OBJECTIVE: To explore the efficacy of compound ciprofloxacin suppository (CCS) combined with Ningbitai (NBT) and Yunnan Baiyao (YB) capsules in the treatment of histological prostatitis with elevated levels of PSA. METHODS: This study included 150 cases of type IIIA histological prostatitis, with PSA levels ranging from 4 to 50 microg/L. After 1 month's treatment with oral Levofloxacin tablets at 0.5 g qd, the PSA levels remained high in 86 patients. Prostate cancer was excluded by transrectal ultrasound-guided prostatic biopsy, and histological prostatitis was confirmed in 65 patients, who were assigned to an experimental group (n=45) and a control group (n=20) to receive CCS combined with NBT and YB capsules and CCS with NBT only, respectively, both for 4 weeks. We determined the PSA levels, obtained NIH-CPSI scores before and after medication, and compared them between the two groups. RESULTS: The two groups were well balanced in demographics and baseline characteristics. After treatment, both showed significant differences in the PSA level, PSA density (PSAD) and CPSI scores from the baseline (P<0.05), and there were also statistically significant differences between the two groups in the changes of the PSA level and CPSI scores after medication (P = 0.029 and 0.001). CONCLUSION:
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Authors | Bao-Xing Huang, Heng-Chuan Su, Fu-Kang Sun |
Journal | Zhonghua nan ke xue = National journal of andrology
(Zhonghua Nan Ke Xue)
Vol. 18
Issue 11
Pg. 986-90
(Nov 2012)
ISSN: 1009-3591 [Print] China |
PMID | 23214247
(Publication Type: Controlled Clinical Trial, English Abstract, Journal Article)
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Chemical References |
- Drugs, Chinese Herbal
- Suppositories
- yunnan baiyao
- Ciprofloxacin
- Prostate-Specific Antigen
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Ciprofloxacin
(administration & dosage, therapeutic use)
- Drug Therapy, Combination
- Drugs, Chinese Herbal
(therapeutic use)
- Humans
- Male
- Middle Aged
- Phytotherapy
- Prostate-Specific Antigen
(blood)
- Prostatitis
(blood, drug therapy, pathology)
- Suppositories
(administration & dosage, therapeutic use)
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