[Mechanisms of cerebral damage in patients with HIV-infection].

Abstract

Mechanisms of HIV transportation through blood-brain barrier, vascular plexus and interaction with cerebral cells having CD-4-receptors, CCR-5- and CXCR-4-coreceptors were studied. Cerebral damage developed through latent and acute periods also known as HIV-encephalopathy, HIV-associated neurocognitive dysfunction etc. Cerebral lesions are caused by a variety of chemical agents from pro-inflammatory cytokines to toxic HIV-proteins resulting in development of HIV-dementia through several years. Even early stage of this process revealed significant disturbances of glucose metabolism and evoked potentials EEG alterations which can serve as a marker of HIV-infection. Genetic differences of HIV in blood and spinal liquor with different drug resistance were revealed implying a new approach to therapy development.

• Authors: N A Beliakov, S V Medvedev, T N Trofimova, V V Rassokhin, N E Dement'eva, S A Shelomov
• Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk (Vestn Ross Akad Med Nauk) Issue 9 Pg. 4-12 ( 2012) ISSN: 0869-6047 [Print] Russia (Federation)
• PMID: 23210166 (Publication Type: Journal Article, Review)

Chemical References

• Anti-HIV Agents

Topics

• AIDS Dementia Complex (diagnosis, drug therapy, physiopathology, virology)
• Anti-HIV Agents (therapeutic use)
• Blood-Brain Barrier (metabolism, physiopathology, virology)
• Central Nervous System (metabolism, physiopathology, virology)
• Drug Resistance, Viral (genetics)
• HIV (genetics, physiology)
• HIV Infections (complications)
• Humans
• Prognosis
• Viral Load (drug effects)
• Virus Physiological Phenomena (drug effects, genetics)