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Evolving spectrum of HIV-associated nephropathy.

AbstractBACKGROUND:
The profile of renal pathology in HIV patients is undergoing significant changes in pattern in the HAART era, with the incidence of HIV-associated nephropathy (HIVAN) decreasing and the incidence of non-HIVAN lesions increasing.
CASE REPORTS:
We describe 2 cases of HIV-infected patients diagnosed with diffuse infiltrative lymphocytosis syndrome (DILS) and coexistent multiple myeloma, an association that has heretofore been unreported. The cases involve a 23-year-old man and a 54-year-old man who presented with renal failure and proteinuria. Kidney biopsy in both revealed DILS and further evaluation revealed both to have multiple myeloma.
CONCLUSION:
DILS is a late complication of AIDS that has become extremely rare in the United States during the HAART era. However, there are patients who present without an AIDS-defining illness or cancers. The development of multiple myeloma in the setting of HIV and DILS presents a novel, heretofore unreported association that may be important to recognize in HIV/AIDS patients with kidney failure.
AuthorsSalman Ahmed, Luan Truong, Garabed Eknoyan, Biruh Workeneh
JournalNephron. Clinical practice (Nephron Clin Pract) Vol. 121 Issue 3-4 Pg. c131-5 ( 2012) ISSN: 1660-2110 [Electronic] Switzerland
PMID23208246 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2012 S. Karger AG, Basel.
Topics
  • AIDS-Associated Nephropathy (complications, diagnosis)
  • Diagnosis, Differential
  • Humans
  • Lymphocytosis (complications, diagnosis)
  • Male
  • Middle Aged
  • Multiple Myeloma (complications, diagnosis)
  • Young Adult

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