Abstract | BACKGROUND: The profile of renal pathology in HIV patients is undergoing significant changes in pattern in the HAART era, with the incidence of HIV-associated nephropathy (HIVAN) decreasing and the incidence of non-HIVAN lesions increasing. CASE REPORTS: We describe 2 cases of HIV-infected patients diagnosed with diffuse infiltrative lymphocytosis syndrome (DILS) and coexistent multiple myeloma, an association that has heretofore been unreported. The cases involve a 23-year-old man and a 54-year-old man who presented with renal failure and proteinuria. Kidney biopsy in both revealed DILS and further evaluation revealed both to have multiple myeloma. CONCLUSION: DILS is a late complication of AIDS that has become extremely rare in the United States during the HAART era. However, there are patients who present without an AIDS-defining illness or cancers. The development of multiple myeloma in the setting of HIV and DILS presents a novel, heretofore unreported association that may be important to recognize in HIV/ AIDS patients with kidney failure.
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Authors | Salman Ahmed, Luan Truong, Garabed Eknoyan, Biruh Workeneh |
Journal | Nephron. Clinical practice
(Nephron Clin Pract)
Vol. 121
Issue 3-4
Pg. c131-5
( 2012)
ISSN: 1660-2110 [Electronic] Switzerland |
PMID | 23208246
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2012 S. Karger AG, Basel. |
Topics |
- AIDS-Associated Nephropathy
(complications, diagnosis)
- Diagnosis, Differential
- Humans
- Lymphocytosis
(complications, diagnosis)
- Male
- Middle Aged
- Multiple Myeloma
(complications, diagnosis)
- Young Adult
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