HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Anti-angiogenesis effect of trichosanthin and the underlying mechanism.

Abstract
The growth and metastasis of tumors depend on angiogenesis. Tumor angiogenesis is initiated by the secretion of growth factors from tumor cells; downstream signals are then triggered in pre-existing blood vessels to sprout a new vascular network. Trichosanthin (TCS) is a type I ribosome-inactivating protein that has anti-tumor activity, but the underlying mechanism remains unclear. In this study, we found that a non-toxic dose of TCS decreased the wound-healing and the migration of H5V mouse heart capillary endothelial cells (ECs) induced by human choriocarcinoma (JAR) cells, as well as the JAR-induced angiogenesis of rat third-order mesenteric arteries. TCS was effective on both tumor cells and ECs/arteries. First, TCS decreased vascular endothelial growth factor transcription and secretion by JAR cells. Second, TCS consequently inhibited the tumor cell-induced, extracellular signal-regulated kinase-mediated angiogenic signal in ECs and blood vessels. In conclusion, the ability of TCS to inhibit tumor angiogenesis contributes to its anti-tumor activity.
AuthorsDongxu He, Jian Jin, Yongtang Zheng, Iain C Bruce, Siucheung Tam, Xin Ma
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 430 Issue 2 Pg. 735-40 (Jan 11 2013) ISSN: 1090-2104 [Electronic] United States
PMID23206700 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier Inc. All rights reserved.
Chemical References
  • Angiogenesis Inhibitors
  • Vascular Endothelial Growth Factor A
  • Trichosanthin
  • Extracellular Signal-Regulated MAP Kinases
Topics
  • Angiogenesis Inhibitors (pharmacology)
  • Animals
  • Cell Line, Tumor
  • Cell Movement (drug effects)
  • Endothelial Cells (drug effects, physiology)
  • Extracellular Signal-Regulated MAP Kinases (antagonists & inhibitors)
  • Humans
  • MAP Kinase Signaling System (drug effects, physiology)
  • Mice
  • Neoplasms (blood supply)
  • Rats
  • Trichosanthin (pharmacology)
  • Vascular Endothelial Growth Factor A (physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: