Efficacy and safety of the SQ-standardized grass allergy immunotherapy tablet in mono- and polysensitized subjects.

Abstract

The efficacy of single-allergen-specific immunotherapy in polysensitized subjects is a matter of debate. We therefore performed a post hoc analysis of pooled data from six randomized, double-blind, placebo-controlled trials (N = 1871) comparing the efficacy and safety of the SQ-standardized grass allergy immunotherapy tablet (AIT), Grazax (Phleum pratense 75 000 SQ-T/2800 BAU, ALK, Denmark), in mono- and polysensitized subjects. A statistically significant reduction in the mean total combined symptom/medication score (TCS) of 27% was demonstrated in actively treated subjects compared with placebo (P < 0.0001). This was not dependent on sensitization status (P = 0.5772), suggesting a similar treatment effect in mono- and polysensitized subjects (i.e. reductions of the TCSs of 28% and 26%, respectively, both P < 0.0001). Finally, a comparable and favourable safety profile of grass AIT was demonstrated in the two subgroups. Thus, no difference in efficacy and safety of single-allergen grass AIT was observed between mono- and polysensitized subjects.

• Authors: H Nelson, M Blaiss, H Nolte, S Ø Würtz, J S Andersen, S R Durham
• Journal: Allergy (Allergy) Vol. 68 Issue 2 Pg. 252-5 (Feb 2013) ISSN: 1398-9995 [Electronic] Denmark
• PMID: 23205670 (Publication Type: Comparative Study, Evaluation Study, Journal Article)
• Copyright: © 2012 John Wiley & Sons A/S.

Chemical References

• Antigens, Plant
• Grazax
• Plant Extracts
• Tablets

Topics

• Administration, Sublingual
• Adult
• Antigens, Plant (immunology)
• Child
• Child, Preschool
• Desensitization, Immunologic (methods)
• Double-Blind Method
• Female
• Follow-Up Studies
• Humans
• Male
• Patient Safety
• Phytotherapy (methods)
• Plant Extracts (therapeutic use)
• Poaceae (immunology)
• Randomized Controlled Trials as Topic
• Rhinitis, Allergic, Seasonal (drug therapy, immunology, physiopathology)
• Risk Assessment
• Severity of Illness Index
• Tablets (administration & dosage)
• Treatment Outcome