Abstract | OBJECTIVE: DESIGN: Prospective controlled study. SETTING: Academic medical center. PATIENT(S): The study population comprised 151 mother/neonate pairs. INTERVENTION(S): Diet and/or insulin administration in GDM(M). MAIN OUTCOME MEASURE(S): Anthropometric, metabolic, hormonal parameters, and OS markers. RESULT(S): The AGEs and AOPPs were higher in PCOS(M) and GDM(M) compared with controls (M). The same significant difference was observed in the corresponding groups of neonates. A strong relationship between mothers and neonates regarding AGEs (r = 0.605) and AOPPs levels (r = 0.735) was disclosed. Analogous findings were observed regarding androgens and insulin resistance in mothers and neonates, respectively. CONCLUSION(S): The present study demonstrated that in PCOS(N), the OS status was similar to that of GDM(N) and strongly associated with their mothers' oxidative status. These findings may have clinical implications, as exposure of PCOS(N) to high OS levels during pregnancy could affect several health issues of neonates.
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Authors | Georgios Boutzios, Sarantis Livadas, Christina Piperi, Nicolaos Vitoratos, Christos Adamopoulos, Dimitrios Hassiakos, Christos Iavazzo, Evanthia Diamanti-Kandarakis |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 99
Issue 3
Pg. 943-50
(Mar 01 2013)
ISSN: 1556-5653 [Electronic] United States |
PMID | 23200689
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Glycated Hemoglobin A
- Glycation End Products, Advanced
- hemoglobin A1c protein, human
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Topics |
- Adult
- Anthropometry
- Biomarkers
(metabolism)
- Diabetes, Gestational
(metabolism)
- Female
- Glycated Hemoglobin
(metabolism)
- Glycation End Products, Advanced
(metabolism)
- Head
(anatomy & histology)
- Humans
- Infant, Newborn
- Multivariate Analysis
- Oxidative Stress
(physiology)
- Polycystic Ovary Syndrome
(metabolism)
- Pregnancy
- Prospective Studies
- Waist-Hip Ratio
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