Biomarkers in uterine leiomyoma.

Abstract

Biomarkers are biologic compounds that are easily accessible and reflect normal physiology or pathology. They are useful in a variety of clinical situations that involve detection of subclinical disease, risk stratification, preoperative planning, and monitoring treatment. A useful intervention needs to exist for a biomarker to be an effective tool. Many compounds have been investigated as potential biomarkers for the diagnosis and surveillance of uterine leiomyomas. Most of these compounds demonstrate subtle differences among patients when leiomyomas are compared with controls. The compounds investigated lack the diagnostic accuracy necessary to add any benefit to the current available modalities used to diagnose and monitor uterine leiomyomas.

• Authors: Gary Levy, Micah J Hill, Torie C Plowden, William H Catherino, Alicia Y Armstrong
• Journal: Fertility and sterility (Fertil Steril) Vol. 99 Issue 4 Pg. 1146-52 (Mar 15 2013) ISSN: 1556-5653 [Electronic] United States
• PMID: 23200685 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Published by Elsevier Inc.

Chemical References

• Biomarkers
• Biomarkers, Tumor

Topics

• Biomarkers (metabolism)
• Biomarkers, Tumor (metabolism)
• Female
• Humans
• Leiomyoma (diagnosis, metabolism)
• Uterine Neoplasms (diagnosis, metabolism)