Abstract | OBJECTIVE: STUDY DESIGN PATIENTS AND MEASUREMENTS: A cross-sectional study involving 87 PCOS (48 obese) and 67 non-PCOS women (36 obese). Anthropometric parameters and body composition were determined. Serum glucose, androgens, FSH, LH, SHBG, insulin, apelin-36, apelin-12, adiponectin, leptin and resistin were measured in the fasting state. RESULTS: Plasma apelin-36 and apelin-12 levels were significantly higher in normal weight women than in the obese women with PCOS (3·1 ± 2·2 vs 1·2 ± 0·7 μg/l, P < 0·001; 2·9 ± 2·4 vs 0·5 ± 0·7 μg/l; P < 0·001 respectively). Both plasma apelin-36 and -12 levels correlated positively with adiponectin levels, and inversely with leptin or resistin levels. There was a negative correlation between plasma apelin-36, apelin-12 and serum LH levels. In addition, an inverse correlation between apelin-12 level and LH to FSH ratio was found. In multiple regression analysis 9% of LH variability was explained by apelin-12 levels (β = -0·14; P < 0·001). CONCLUSIONS: Nutritional status seems to have different effects on apelin release, particularly, its active isoform, in women with PCOS compared with women without PCOS. This may be partially caused by changes in leptin and resistin secretion and may enhance pituitary-ovarian axis disturbances. The association between both isoforms of apelin and insulin resistance seems to be bidirectional.
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Authors | Magdalena Olszanecka-Glinianowicz, Paweł Madej, Marcin Nylec, Aleksander Owczarek, Wojciech Szanecki, Piotr Skałba, Jerzy Chudek |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 79
Issue 2
Pg. 238-42
(Aug 2013)
ISSN: 1365-2265 [Electronic] England |
PMID | 23199261
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2012 John Wiley & Sons Ltd. |
Chemical References |
- APLN protein, human
- Adiponectin
- Apelin
- Blood Glucose
- Insulin
- Intercellular Signaling Peptides and Proteins
- Leptin
- Resistin
- apelin-12 peptide
- Luteinizing Hormone
- Follicle Stimulating Hormone
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Topics |
- Adiponectin
(blood)
- Adult
- Apelin
- Blood Glucose
(metabolism)
- Cross-Sectional Studies
- Fasting
- Female
- Follicle Stimulating Hormone
(blood)
- Humans
- Insulin
(blood)
- Insulin Resistance
- Intercellular Signaling Peptides and Proteins
(blood)
- Leptin
(blood)
- Luteinizing Hormone
(blood)
- Nutritional Status
- Obesity
(blood, complications)
- Polycystic Ovary Syndrome
(blood, complications)
- Resistin
(blood)
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