Expression of galactose-1-p-uridyltransferase in Chinese hamster x human galactosemia somatic cell hybrids.

Abstract	Lymphocytes from a patient with classic galactosemia (GALT deficiency) were hybridized with a Chinese hamster cell line. Electrophoretic valuation of GALT in 31 independently derived interspecific hybrid clones failed to demonstrate expression of the human GALT gene even when human chromosome 9 was present. Possible mechanisms for this lack of expression are presented.
Authors	R S Sparkes, T Mohandas, M C Sparkes, J D Shulkin
Journal	Biochemical genetics (Biochem Genet) Vol. 17 Issue 7-8 Pg. 683-92 (Aug 1979) ISSN: 0006-2928 [Print] United States
PMID	231967 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Nucleotidyltransferases UTP-Hexose-1-Phosphate Uridylyltransferase
Topics	Animals Cell Line Chromosome Mapping Chromosomes, Human, 6-12 and X Clone Cells Cricetinae Cricetulus Galactosemias (genetics) Genes Humans Hybrid Cells Lymphocytes Nucleotidyltransferases (genetics) UTP-Hexose-1-Phosphate Uridylyltransferase (genetics)

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