Topical antiinflammatory activity of the major lipophilic constituents of the rhizome of Zingiber cassumunar. Part I: The essential oil.

Abstract

The essential oil of the rhizome of Zingiber cassumunar was found to exhibit a topical antiinflammatory effect, when tested using the model of carrageenan-induced hind paw edema in rats (ID(50) = 22 mg oil/paw). Individual assessment of topical antiinflammatory activity of the five major components of the oil demonstrated that (E)-1-(3,4-dimethoxyphenyl)butadiene (DMPBD), terpinen-4-ol and α-terpinene significantly inhibited edema formation, whereas sabinene and γ-terpinene were inactive up to 6 mg/paw. The most active compound, DMPBD, was found to be an antiinflammatory agent twice as potent as the reference drug diclofenac (ID(50) = 3 vs 6 mg/paw, respectively).

• Authors: U Pongprayoon, P Soontornsaratune, S Jarikasem, T Sematong, S Wasuwat, P Claeson
• Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology (Phytomedicine) Vol. 3 Issue 4 Pg. 319-22 (Feb 1997) ISSN: 0944-7113 [Print] Germany
• PMID: 23195188 (Publication Type: Journal Article)
• Copyright: Copyright © 1996 Gustav Fischer Verlag. Published by Elsevier GmbH.. All rights reserved.