Effects of linalool on inflammation, matrix accumulation and podocyte loss in kidney of streptozotocin-induced diabetic rats.

Abstract

CONTEXT:

This study aimed to evaluate the renoprotective action of linalool (LIN) on streptozotocin (STZ)-induced diabetic rats.

OBJECTIVE:

The pathological changes in diabetic nephropathy (DN) include oxidative stress, renal injury, matrix accumulation and podocyte abnormalities. We investigated the renoprotective actions of LIN, a monoterpene alcohol, present in herbal essential oils in STZ-induced diabetic rats with renal injury.

MATERIALS AND METHODS:

STZ-diabetic rats were administered LIN (25 mg/kg) for 45 days, after which the activities of key enzymes of glucose metabolism, collagen content, oxidative damage and expression of glucose transporter-1 (GLUT-1), transforming growth factor-β1 (TGF-β1), nuclear factor-κBp65 (NF-κB p65) and nephrin were analyzed.

RESULTS:

Diabetic rats displayed altered glucose metabolism, collagen accumulation and increased TGF-β1 and NF-κB expression in kidney. LIN treatment restored glucose-metabolizing enzymes, collagen content and GLUT-1 expression and also prevented nephrin loss. LIN also rescued kidney from oxidative stress and inflammation by decreasing the expression of TGF-β1 and NF-κB. Ultrastructural changes such as basement membrane thickening, reduction in podocyte number and loss of filtration barrier integrity in diabetic rats were mitigated by LIN.

DISCUSSION AND CONCLUSION:

The results of this study suggest that LIN can attenuate nephropathic changes induced in kidney of diabetic rats. These findings highlight the utility of LIN as a potential drug to treat renal damage in diabetic subjects.

• Authors: Balasubramaniam Deepa, Carani Venkatraman Anuradha
• Journal: Toxicology mechanisms and methods (Toxicol Mech Methods) Vol. 23 Issue 4 Pg. 223-34 (May 2013) ISSN: 1537-6524 [Electronic] England
• PMID: 23193997 (Publication Type: Journal Article)

Chemical References

• Acyclic Monoterpenes
• Anti-Inflammatory Agents
• Biomarkers
• Monoterpenes
• Streptozocin
• linalool

Topics

• Acyclic Monoterpenes
• Animals
• Anti-Inflammatory Agents (administration & dosage, therapeutic use)
• Biomarkers (metabolism)
• Diabetes Mellitus, Experimental (complications, immunology, metabolism, pathology)
• Diabetic Nephropathies (immunology, metabolism, pathology, prevention & control)
• Extracellular Matrix (drug effects, immunology, metabolism)
• Kidney (drug effects, immunology, metabolism, ultrastructure)
• Male
• Microscopy, Electron, Transmission
• Monoterpenes (administration & dosage, therapeutic use)
• Podocytes (drug effects, pathology)
• Rats
• Rats, Wistar
• Streptozocin (pharmacology)