Activation of complement by circulating immune complexes isolated from leprosy patients.

Abstract

Circulating immune complexes isolated from different types of leprosy sera as polyethylene glycol (PEG) precipitates were found to be efficient activators of the alternative pathway of complement. PEG precipitates from BL/LL leprosy patients and those with erythema nodosum leprosum were found to activate both the classical pathway and the alternative pathway of complement efficiently, while PEG precipitates from TT/BT leprosy patients and borderline tuberculoid patients in reaction were found to active the alternative pathway of complement but not the classical pathway. No significant differences were observed between the PEG precipitates from reactional and nonreactional TT/BT and BL/LL patients in their complement activating ability.

• Authors: P Tyagi, V D Ramanathan, B K Girdhar, K Katoch, A S Bhatia, U Sengupta
• Journal: International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association (Int J Lepr Other Mycobact Dis) Vol. 58 Issue 1 Pg. 31-8 (Mar 1990) ISSN: 0148-916X [Print] United States
• PMID: 2319186 (Publication Type: Journal Article)

Chemical References

• Antigen-Antibody Complex
• Blood Proteins
• Polyethylene Glycols

Topics

• Antigen-Antibody Complex (blood, immunology)
• Blood Proteins (analysis)
• Chemical Precipitation
• Complement Activation (immunology)
• Complement Hemolytic Activity Assay
• Complement Pathway, Alternative
• Erythema Nodosum (immunology)
• Humans
• Leprosy (immunology)
• Leprosy, Borderline (immunology)
• Leprosy, Lepromatous (immunology)
• Leprosy, Tuberculoid (immunology)
• Polyethylene Glycols