Abstract | BACKGROUND: Organ transplant recipients (OTRs) taking immunosuppressants are at high risk of skin cancer, which is the most common malignant condition in OTRs, so dermatologic surveillance is important for OTRs. OBJECTIVES: To characterize the most common skin cancers arising from chronic immunosuppression in OTRs. METHODS: A PubMed search for retrospective single- and multicenter studies reporting skin cancer incidence from 2006 to 2010 was undertaken. Data regarding each study's immunosuppressive regimen, affected skin cancer cohort, and associated risk factors were extracted. RESULTS: CONCLUSION: Sun education programs and frequent screenings in organ transplant clinics have provided the best preventative strategies after transplantation, although the characteristics of the immunosuppressive regimen also play an important role. Thus, the adjuvant strategy of modifying immunosuppression may be effective when confronting severe transplant-associated skin cancer. Although the decision-making process for curbing levels of immunosuppression is difficult, further long-term, randomized controlled studies should assess the effect of using less immunosuppressant medication while preserving graft function.
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Authors | Tejaswi Mudigonda, Michelle M Levender, Jenna L O'Neill, Cameron E West, Daniel J Pearce, Steven R Feldman |
Journal | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
(Dermatol Surg)
Vol. 39
Issue 3 Pt 1
Pg. 345-64
(Mar 2013)
ISSN: 1524-4725 [Electronic] United States |
PMID | 23190408
(Publication Type: Journal Article, Multicenter Study)
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Copyright | © 2012 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc. |
Chemical References |
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Topics |
- Age Factors
- Carcinoma, Merkel Cell
(epidemiology, etiology, prevention & control)
- Female
- Humans
- Immunosuppression Therapy
(methods)
- Immunosuppressive Agents
(adverse effects)
- Incidence
- Male
- Melanoma
(epidemiology, etiology, prevention & control)
- Organ Transplantation
- Postoperative Complications
- Retrospective Studies
- Risk Factors
- Sarcoma, Kaposi
(epidemiology, etiology, prevention & control)
- Sex Factors
- Skin Neoplasms
(epidemiology, etiology, prevention & control)
- Sunlight
(adverse effects)
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