[Synthesis and anti-tumor properties of myelopeptide MP-1].

Abstract

We have studied anti-tumor properties of bone marrow derived peptide Phe-Leu-Gly-Phe-Pro-Thr (MP-1) synthesized by classical methods. It was shown that MP-1 enhanced the effect ofcytostatic therapy of lymphatic leukemia P388 and increased latent growth period of P388 tumors implanted in irradiated mice. MP-1 also decreased metastasis of mouse breast adenocarcinoma Ca-755 after surgery.

• Authors: L A Fonina, E M Treshchalina, R G Belevskaia, A A Az'muko, M A Efremov, L A Sedakova, E A Kirilina
• Journal: Bioorganicheskaia khimiia (Bioorg Khim) 2012 Jul-Aug Vol. 38 Issue 4 Pg. 406-12 ISSN: 0132-3423 [Print] Russia (Federation)
• PMID: 23189554 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Oligopeptides
• myelopeptides
• Cisplatin

Topics

• Animals
• Antineoplastic Agents (administration & dosage, chemical synthesis)
• Cell Line, Tumor
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Leukemia P388 (drug therapy, radiotherapy)
• Mice
• Oligopeptides (administration & dosage, chemical synthesis)