Abstract | BACKGROUND: Sonchus asper is traditionally used in Pakistan for the treatment of reproductive dysfunction and oxidative stress. The present investigation was aimed to evaluate chloroform extract of Sonchus asper (SACE) against potassium bromate-induced reproductive stress in male rats. METHODS: 20 mg/kg body weight (b.w.) potassium bromate (KBrO3) was induced in 36 rats for four weeks and checked the protective efficacy of SACE at various hormonal imbalances, alteration of antioxidant enzymes, and DNA fragmentation levels. High performance chromatography (HPLC) was used for determination of bioactive constituents responsible. RESULTS: CONCLUSION: Protective effects of Sonchus asper vs. KBrO3 induced lipid peroxidation might be due to bioactive compound present in SACE.
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Authors | Rahmat Ali Khan, Muhammad Rashid Khan, Sumaira Sahreen |
Journal | Lipids in health and disease
(Lipids Health Dis)
Vol. 11
Pg. 164
(Nov 27 2012)
ISSN: 1476-511X [Electronic] England |
PMID | 23186106
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Bromates
- Enzymes
- Hormones
- Plant Extracts
- Protective Agents
- potassium bromate
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Topics |
- Animals
- Antioxidants
(metabolism)
- Bromates
(toxicity)
- DNA Fragmentation
(drug effects)
- Enzymes
(blood, metabolism)
- Hormones
(blood, metabolism)
- Lipid Peroxidation
(drug effects)
- Male
- Plant Extracts
(chemistry, pharmacology)
- Protective Agents
(chemistry, pharmacology)
- Rats
- Sonchus
(chemistry)
- Testis
(drug effects, metabolism, pathology)
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