[Quantitative study of the medullar fibrosis in 84 cases of idiopathic myeloid splenomegaly (author's transl)].

Abstract

84 bone marrow biopsies were analysed by quantification methods with Classimat. The initial diagnosis was: idiopathic myelofibrosis with splenomegaly. A previous study divided the patients among three categories, according to the classification in three progressive stages of the bone marrow disease. The quantitative lecture was done after reticulin coloration, "in blind", and on several biopsies from the same patient. The results show good correlation with classical histologic methods. The quantitative measure of fibrosis is already important as soon as the first stages of the disease. Correlations with prognosis are more difficult to define.

• Authors: J Dumont, P d'Athis, N Atken, J L Binet, J Ripault, W Worhauer, J Bernard
• Journal: La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris (Sem Hop) 1979 Oct 18-25 Vol. 55 Issue 35-36 Pg. 1623-8 France
• Vernacular Title: Etude quantitative de la fibrose médullaire dans 84 cas de splénomégalie myéloïde primitive.
• PMID: 231834 (Publication Type: English Abstract, Journal Article)

Chemical References

• Reticulin

Topics

• Bone Marrow (analysis, pathology)
• Humans
• Primary Myelofibrosis (complications, metabolism, pathology)
• Prognosis
• Reticulin (analysis)
• Splenomegaly (complications, metabolism, pathology)