Abstract | BACKGROUND: METHODS: RESULTS: The results indicated that treatment with crocin at doses of 30, 60, and 120 mg/kg significantly decreased infarct volume by 64%, 74%, and 73%, respectively. Administration of crocin (60 mg/kg) 1 hour before, at the start, or 1 hour after ischemia reduced brain edema by 48%, 52%, and 51%, respectively. Moreover, crocin (60 mg/kg) significantly reduced malondialdehyde (MDA) content and increased activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in the ischemic cortex (P< .001). CONCLUSIONS:
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Authors | Abedin Vakili, Mohammad Reza Einali, Ahmad Reza Bandegi |
Journal | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
(J Stroke Cerebrovasc Dis)
Vol. 23
Issue 1
Pg. 106-13
(Jan 2014)
ISSN: 1532-8511 [Electronic] United States |
PMID | 23182363
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Antioxidants
- Carotenoids
- Malondialdehyde
- crocin
- Glutathione Peroxidase
- Superoxide Dismutase
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Topics |
- Animals
- Antioxidants
(metabolism)
- Behavior, Animal
(drug effects)
- Body Water
(metabolism)
- Brain
(enzymology, pathology)
- Brain Edema
(drug therapy)
- Brain Ischemia
(prevention & control)
- Carotenoids
(therapeutic use)
- Cerebral Infarction
(pathology, prevention & control)
- Cerebrovascular Circulation
(drug effects)
- Dose-Response Relationship, Drug
- Glutathione Peroxidase
(metabolism)
- Male
- Malondialdehyde
(metabolism)
- Rats
- Rats, Wistar
- Stroke
(prevention & control)
- Superoxide Dismutase
(metabolism)
- Treatment Outcome
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