PGE₂ and BMP-2 in bone and cartilage metabolism: 2 intertwining pathways.

Abstract

Osteoarthritis and lesions to cartilage tissue are diseases that frequently result in impaired joint function and patient disability. The treatment of osteoarthritis, along with local bone defects and systemic skeletal diseases, remains a significant clinical challenge for orthopaedic surgeons. Several bone morphogenetic proteins (BMPs) are known to have osteoinductive effects, whereof BMP-2 and BMP-7 are already approved for clinical applications. There is growing evidence that the metabolism of bone as well as the cartilage damage associated with the above disease processes are strongly inter-related with the interactions of the inflammation-related pathways (in particular prostaglandin E₂ (PGE₂)) and osteogenesis (in particular bone morphogenetic protein-2 (BMP-2)). There is strong evidence that the pathways of prostaglandins and bone morphogenetic proteins are intertwined, and they have recently come into focus in several experimental and clinical studies. This paper focuses on PGE₂ and BMP-2 intertwining pathways in bone and cartilage metabolism, and summarizes the recent experimental and clinical data.

• Authors: Marcel Haversath, Isabelle Catelas, Xinning Li, Tjark Tassemeier, Marcus Jäger
• Journal: Canadian journal of physiology and pharmacology (Can J Physiol Pharmacol) Vol. 90 Issue 11 Pg. 1434-45 (Nov 2012) ISSN: 1205-7541 [Electronic] Canada
• PMID: 23181272 (Publication Type: Journal Article, Review)

Chemical References

• Bone Morphogenetic Protein 2
• Dinoprostone

Topics

• Animals
• Bone Morphogenetic Protein 2 (metabolism)
• Bone Remodeling
• Bone and Bones (immunology, injuries, metabolism)
• Cartilage (immunology, injuries, metabolism)
• Dinoprostone (metabolism)
• Humans
• Osteoblasts (immunology, metabolism)
• Osteoclasts (immunology, metabolism)
• Signal Transduction