Protective effects of sinapic acid on cardiac hypertrophy, dyslipidaemia and altered electrocardiogram in isoproterenol-induced myocardial infarcted rats.

Abstract

Lipids and lipoproteins play a vital role in the pathogenesis of myocardial infarction. There are no studies reported on the protective effects of sinapic acid on changes in electrocardiogram, lipids and lipoproteins in myocardial infarction. This study aims to evaluate the protective effects of sinapic acid on cardiac hypertrophy, dyslipidaemia and alterations in lipoproteins and electrocardiogram in isoproterenol-induced myocardial infarcted rats. Rats were pre- and co-treated with sinapic acid (12 mg/kg body weight) daily for a period of 10 days and were induced myocardial infarction with isoproterenol (100mg/kg body weight) on 9th and 10th day. Isoproterenol induced rats showed an increased level of serum cardiac troponin-T and elevated ST-segments. Increased levels of serum and heart cholesterol, triglycerides and free fatty acids were observed in isoproterenol induced rats. Isoproterenol also increased serum low density and very low density lipoprotein cholesterol and decreased high density lipoprotein cholesterol. The activity of liver 3-hydroxy-3-methyl glutaryl-coenzyme-A-reductase was elevated in isoproterenol induced rats. The in vitro study revealed the potent antioxidant activity of sinapic acid. Pre- and co-treatment with sinapic acid ameliorated cardiac hypertrophy, dyslipidemia and elevated ST-segments in isoproterenol induced myocardial infarcted rats. Thus, sinapic acid prevented the alterations in the levels of lipids and lipoproteins by virtue of its antilipidaemic effect in isoproterenol induced myocardial infarcted rats.

• Authors: Subhro Jyoti Roy, P Stanely Mainzen Prince
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 699 Issue 1-3 Pg. 213-8 (Jan 15 2013) ISSN: 1879-0712 [Electronic] Netherlands
• PMID: 23178800 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier B.V. All rights reserved.

Chemical References

• Antioxidants
• Coumaric Acids
• Hypolipidemic Agents
• Lipids
• Troponin T
• sinapinic acid
• Hydroxymethylglutaryl CoA Reductases
• Isoproterenol

Topics

• Animals
• Antioxidants (administration & dosage, pharmacology)
• Cardiomegaly (drug therapy)
• Coumaric Acids (administration & dosage, pharmacology)
• Dyslipidemias (drug therapy)
• Electrocardiography
• Hydroxymethylglutaryl CoA Reductases (drug effects, metabolism)
• Hypolipidemic Agents (administration & dosage, pharmacology)
• Isoproterenol (toxicity)
• Lipids (blood)
• Male
• Myocardial Infarction (drug therapy, physiopathology)
• Rats
• Rats, Wistar
• Troponin T (blood)