Abstract | ETHNOPHARMACOLOGICAL RELEVANCE:
Wuling Capsule is a single herbal formula from mycelia of precious Xylaria nigripes (Kl.) Sacc and its pharmacological function have a tranquilizing effect on the central nervous system. The aim of the study to evaluate the efficacy and safety of Wuling capsule in treatment of insomnia. MATERIALS AND METHODS: We performed a multicenter, randomized, double-blind, placebo-controlled study. The participants received either placebo (n=92) or Wuling capsule (n=94) for 4 weeks and a follow-up period for 2 weeks. RESULTS: Compared between pre-treatment and post-treatment, the global Pittsburgh sleep quality index (PSQI) scores in both Wuling capsule group and placebo group improved significantly (P<0.01). However, there was no significant difference between Wuling capsule group and placebo group (P>0.05). Scores of clinical global impressions scale (CGI-I) at each week in Wuling capsule group was similar to those in placebo group (P>0.05). Compared between pre-treatment and post-treatment, scores of the four components of world health organization on quality of life brief scale (WHOQOL-BREF) in both Wuling capsule group and placebo group improved significantly (P<0.01). However, there were no difference between the two groups (P>0.05). The rate of adverse events was 10.10% in Wuling group, and 6.73% in placebo group (P>0.05). CONCLUSIONS:
Wuling capsule can improve insomnia when compared with pre-treatment for 4 weeks and be a well tolerated by all the patients at the 6 weeks of study period. However, there are no significant in the results of the variables tested when compared with placebo control. Further additional rigorous randomized clinical trials are still required.
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Authors | Yan Lin, Xiao-yun Wang, Ren Ye, Wan-hua Hu, Shu-chen Sun, Hong-juan Jiao, Xiu-hua Song, Zheng-zhong Yuan, Yuan-yuan Zheng, Guo-qing Zheng, Jin-Cai He |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 145
Issue 1
Pg. 320-7
(Jan 09 2013)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 23178661
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Capsules
- Drugs, Chinese Herbal
- Hypnotics and Sedatives
- wuling
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Topics |
- Adolescent
- Adult
- Capsules
(administration & dosage)
- Double-Blind Method
- Drugs, Chinese Herbal
(administration & dosage, adverse effects, therapeutic use)
- Female
- Humans
- Hypnotics and Sedatives
(administration & dosage, adverse effects, therapeutic use)
- Male
- Middle Aged
- Phytotherapy
(adverse effects, methods)
- Quality of Life
- Severity of Illness Index
- Sleep Initiation and Maintenance Disorders
(drug therapy)
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