HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effect of dietary molybdenum on esophageal carcinogenesis in rats induced by N-methyl-N-benzylnitrosamine.

Abstract
The influence of dietary molybdenum on esophageal carcinogenesis induced by N-methyl-N-benzylnitrosamine (2.5 mg per kg of body weight once a week for 20 wk s.c.) was studied in male F344 rats. The tumor incidence and tumor development in the esophagus were significantly lower in the rats in the high-molybdenum (2 ppm) diet group than in the rats in the low-molybdenum (0.032 ppm) diet group; i.e., 44.4% (0.6 +/- 0.8) and 73.2% (2.2 +/- 2.0), respectively. The molybdenum levels in the esophagus-forestomach, liver, and serum were significantly higher in the high-molybdenum diet group than in the low-molybdenum diet group. Xanthine oxidase activity in the esophagus and forestomach in the high-molybdenum diet group was significantly higher than that in the low-molybdenum diet group, whereas liver and serum xanthine oxidase activities were not significantly different between these two groups. These results suggest that xanthine oxidase in the esophagus plays a significant role in the inhibitory effect of molybdenum on esophageal carcinogenesis.
AuthorsH Komada, Y Kise, M Nakagawa, M Yamamura, K Hioki, M Yamamoto
JournalCancer research (Cancer Res) Vol. 50 Issue 8 Pg. 2418-22 (Apr 15 1990) ISSN: 0008-5472 [Print] United States
PMID2317826 (Publication Type: Journal Article)
Chemical References
  • Carcinogens
  • Molybdenum
  • nitrosobenzylmethylamine
  • Dimethylnitrosamine
Topics
  • Animals
  • Body Weight (drug effects)
  • Carcinogens (toxicity)
  • Diet
  • Dimethylnitrosamine (toxicity)
  • Dose-Response Relationship, Drug
  • Esophageal Neoplasms (chemically induced, pathology, prevention & control)
  • Esophagus (drug effects, pathology)
  • Male
  • Molybdenum (administration & dosage, therapeutic use)
  • Rats
  • Rats, Inbred F344

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: