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Cyclophilin inhibitors for hepatitis C therapy.

Abstract
This article highlights a unique time in the history of hepatitis C therapy. In the last few years new families of direct-acting antivirals have emerged, that block different viral proteins to interrupt viral replication, such as protease, NS5A inhibitors, and NS5B inhibitors. There are few host-targeted agents in development; currently cyclophilin inhibitors are the only host-targeted agents in advanced development. One of these new agents has now progressed to phase 3 clinical trials; in this review article their potential role as a future therapy to cure hepatitis C is discussed.
AuthorsFernando E Membreno, Jennifer C Espinales, Eric J Lawitz
JournalClinics in liver disease (Clin Liver Dis) Vol. 17 Issue 1 Pg. 129-39 (Feb 2013) ISSN: 1557-8224 [Electronic] United States
PMID23177289 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2013 Elsevier Inc. All rights reserved.
Chemical References
  • Antiviral Agents
  • Cyclosporins
  • Enzyme Inhibitors
  • Interferon-alpha
  • Recombinant Proteins
  • Viral Nonstructural Proteins
  • Polyethylene Glycols
  • Ribavirin
  • Cyclosporine
  • (melle-4)cyclosporin
  • NS-5 protein, hepatitis C virus
  • Cyclophilins
  • peginterferon alfa-2a
  • alisporivir
  • SCY-635
Topics
  • Antiviral Agents (therapeutic use)
  • Cyclophilins (antagonists & inhibitors)
  • Cyclosporine (therapeutic use)
  • Cyclosporins (therapeutic use)
  • Drug Therapy, Combination
  • Enzyme Inhibitors (therapeutic use)
  • Hepacivirus (enzymology, genetics)
  • Hepatitis C (drug therapy)
  • Humans
  • Interferon-alpha (therapeutic use)
  • Polyethylene Glycols (therapeutic use)
  • Recombinant Proteins (therapeutic use)
  • Ribavirin (therapeutic use)
  • Viral Nonstructural Proteins (antagonists & inhibitors)

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