Abstract |
Nipah virus (NiV) and Hendra virus (HeV) are closely related, recently emerged paramyxoviruses that are capable of causing considerable morbidity and mortality in several mammalian species, including humans. Henipavirus-specific vaccines are still commercially unavailable, and development of novel antiviral strategies to prevent lethal infections due to henipaviruses is highly desirable. Here we describe the development of adeno-associated virus (AAV) vaccines expressing the NiV G protein. Characterization of these vaccines in mice demonstrated that a single intramuscular AAV injection was sufficient to induce a potent and long-lasting antibody response. Translational studies in hamsters further demonstrated that all vaccinated animals were protected against lethal challenge with NiV. In addition, this vaccine induced a cross-protective immune response that was able to protect 50% of the animals against a challenge by HeV. This study presents a new efficient vaccination strategy against henipaviruses and opens novel perspectives on the use of AAV vectors as vaccines against emergent diseases.
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Authors | Aurélie Ploquin, Judit Szécsi, Cyrille Mathieu, Vanessa Guillaume, Véronique Barateau, Kien Chai Ong, Kum Thong Wong, François-Loïc Cosset, Branka Horvat, Anna Salvetti |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 207
Issue 3
Pg. 469-78
(Feb 01 2013)
ISSN: 1537-6613 [Electronic] United States |
PMID | 23175762
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Neutralizing
- Antibodies, Viral
- Immunoglobulin G
- Vaccines, Synthetic
- Viral Vaccines
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Topics |
- Animals
- Antibodies, Neutralizing
(immunology)
- Antibodies, Viral
(immunology)
- Cell Line, Tumor
- Cricetinae
- Dependovirus
(genetics)
- Disease Models, Animal
- Genetic Vectors
(genetics)
- Henipavirus Infections
(immunology, prevention & control, virology)
- Humans
- Immunity, Humoral
- Immunoglobulin G
(immunology)
- Male
- Mice
- Vaccines, Synthetic
(genetics, immunology)
- Viral Vaccines
(genetics, immunology)
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