Higher plasma
visfatin concentration has been associated with clinical outcomes of
traumatic brain injury. No published information exists to date about change in plasma
visfatin after
intracerebral hemorrhage. This study included one hundred and twenty-eight healthy controls and 128 patients with
intracerebral hemorrhage. The unfavorable outcome was defined as modified Rankin Scale score >2 at 6 months. The patients had higher plasma
visfatin measurements than control subjects. Plasma
visfatin levels were highly correlated with National Institutes of Health
Stroke Scale score and plasma
C-reactive protein levels in the patients. A multivariate analysis identified plasma
visfatin level as an independent predictor for 6-month mortality and unfavorable outcome. According to receiver operating characteristic curve analysis, the predictive value of the plasma
visfatin concentration was similar to National Institutes of Health
Stroke Scale score. In a combined logistic-regression model,
visfatin improved the predictive value of National Institutes of Health
Stroke Scale score for 6-month unfavorable outcome. Thus, increased plasma
visfatin level is associated with 6-month clinical outcomes after
intracerebral hemorrhage.