Abstract | OBJECTIVE: [corrected] The Rh-hemolytic disease can lead to a late anemia by hemolytic and hyporigenerative mechanism. We compared the effectiveness of rHuEPO in two care protocols that differ for doses of rHuEPO administrated and for timing of administration. METHODS: A cohort of 14 neonates was investigated. The neonates were treated with two different protocols. Protocol A: a dose of 200 U/kg/day of rHuEpo administered subcutaneously starting from the end of the second week of life; Protocol B: a dose of 400 U/kg/day of rHuEpo administered subcutaneously starting from the end of the first week of life. RESULTS: The hematocrit values in the protocol A group decreased during treatment (32,5% vs 25,2%), whereas the hematocrit value in protocol B group remained almost stable (38,7% vs 42,8%). The mean numbers of platelets remained stable in both groups while neutrophils increased in protocol A group and decreased in protocol B (p<0,05). Reticulocyte count increased during treatment in both groups, although only in protocol B group it was statistically significative (p<0,05). CONCLUSIONS: Our results suggest a similar efficacy between the two treatment protocols. Increasing doses of rHuEPO do not seem enhancing their effectiveness and the incidence of side effects.
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Authors | A A Zuppa, G Alighieri, A Fracchiolla, P Catenazzi, A D'Antuono, R Riccardi, M Cavani, C Romagnoli |
Journal | La Pediatria medica e chirurgica : Medical and surgical pediatrics
(Pediatr Med Chir)
2012 Jul-Aug
Vol. 34
Issue 4
Pg. 186-91
ISSN: 0391-5387 [Print] Italy |
PMID | 23173411
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Algorithms
- Anemia, Neonatal
(drug therapy, etiology)
- Cohort Studies
- Erythropoietin
(administration & dosage)
- Hematocrit
- Humans
- Infant, Newborn
- Injections, Subcutaneous
- Reticulocyte Count
- Rh Isoimmunization
(complications, therapy)
- Treatment Outcome
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