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Opposing consequences of signaling through EGF family members: Escape from CTLs could be a bait for NK cells.

Abstract
Oncogenes have been traditionally viewed as molecular drivers for tumor growth and survival. Recent evidence indicates that oncogenes may facilitate the escape of malignant cells from immune recognition and elimination. In this article, we discuss the implications of the overexpression of epidermal growth factor receptor (EGFR) family members on immune escape of tumors and immunotherapy.
AuthorsRolf Kiessling, Riki Okita, Dimitrios Mougiakakos, Yumeng Mao, Dhifaf Sarhan, Erik Wennerberg, Barbara Seliger, Andreas Lundqvist, Kousaku Mimura, Koji Kono
JournalOncoimmunology (Oncoimmunology) Vol. 1 Issue 7 Pg. 1200-1201 (Oct 01 2012) ISSN: 2162-4011 [Print] United States
PMID23170279 (Publication Type: Journal Article)

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