Toll-like receptor 5 agonism protects mice from radiation pneumonitis and pulmonary fibrosis.

Abstract

Radiation pneumonitis and pulmonary fibrosis are the main complications with radiotherapy for thoracic neoplasms, directly limiting the efficient dose in clinical application and currently there are few medicines that effectively function as radioprotectants. However, a TLR5 agonist, CBLB502, was confirmed to have protective efficacy against hematopoietic and gastrointestinal radiation syndromes in mice and primates. This study points to a new direction for protection against thoracic radiation-induced pulmonary syndromes and skin injury by CBLB502. We utilized the TUNEL assay, pathological analysis and immunohistochemistry to obtain evidence that CBLB502 could alleviate the occurrence of radiation pneumonitis and pulmonary fibrosis as well as radiation- induced skin injury. It may thus play a promising role in facilitating clinical radiotherapy of thoracic neoplasms.

• Authors: Zhi-Dong Wang, Yu-Lei Qiao, Xi-Feng Tian, Xue-Qing Zhang, Shi-Xiang Zhou, Hai-Xiang Liu, Ying Chen
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 13 Issue 9 Pg. 4763-7 ( 2012) ISSN: 2476-762X [Electronic] Thailand
• PMID: 23167416 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CBLB502
• Laminin
• Peptides
• Pulmonary Surfactant-Associated Protein B
• Radiation-Protective Agents
• Toll-Like Receptor 5

Topics

• Animals
• Apoptosis (drug effects, radiation effects)
• Laminin (metabolism)
• Lung (radiation effects)
• Male
• Mice
• Mice, Inbred C57BL
• Peptides (pharmacology, therapeutic use)
• Pulmonary Fibrosis (metabolism, pathology, prevention & control)
• Pulmonary Surfactant-Associated Protein B (metabolism)
• Radiation Injuries, Experimental (metabolism, pathology, prevention & control)
• Radiation Pneumonitis (metabolism, pathology, prevention & control)
• Radiation-Protective Agents (pharmacology, therapeutic use)
• Skin Ulcer (etiology, prevention & control)
• Toll-Like Receptor 5 (agonists, metabolism)