Monoclonal antibody HML-1, a marker for intraepithelial T cells and lymphomas derived thereof, also recognizes hairy cell leukemia and some B-cell lymphomas.

Abstract

Current views regard monoclonal antibody HML-1 as an exquisite marker for intraepithelial T cells and primary intestinal and cutaneous T-cell lymphomas. We show that HML-1 reacted with 11 of 12 cases of hairy cell leukemia, with 1 of 13 cases of primary gastrointestinal B-cell lymphoma, and with an unclassified large-cell B lymphoma of the thoracic wall. We conclude that HML-1 is not restricted to the T-cell lineage and that the HML-1 antigen is expressed in a small subset of both T- and B-cell neoplasms.

• Authors: P Möller, B Mielke, G Moldenhauer
• Journal: The American journal of pathology (Am J Pathol) Vol. 136 Issue 3 Pg. 509-12 (Mar 1990) ISSN: 0002-9440 [Print] United States
• PMID: 2316623 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Biomarkers, Tumor

Topics

• Antibodies, Monoclonal (analysis, immunology)
• B-Lymphocytes (analysis, immunology, pathology)
• Biomarkers, Tumor (analysis, immunology)
• Epithelium (analysis, immunology, pathology)
• Gastrointestinal Neoplasms (analysis, diagnosis, immunology)
• Humans
• Immunohistochemistry
• Leukemia, Hairy Cell (diagnosis, immunology)
• Lymphoma (analysis, diagnosis, immunology)
• T-Lymphocytes (analysis, immunology, pathology)
• Thoracic Neoplasms (analysis, diagnosis, immunology)