HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Gram-negative bacillary pneumonia in the nosocomial setting. Role of aztreonam therapy.

Abstract
Gram-negative bacterial pneumonia is the leading cause of fatal nosocomial infection in this country. Predisposing factors include altered upper respiratory tract flora and altered barriers that normally protect the sterile lower respiratory tract from invasion by pharyngeal bacteria. Aztreonam, which is highly active against most gram-negative pathogens and which does not cause nephrotoxicity, has been evaluated in the treatment of nosocomial pneumonia. In vitro and pharmacokinetic data on aztreonam indicate that this agent provides an alternative agent for use when resistance to cephalosporin and aminoglycoside antibiotics has developed. Data further suggest that aztreonam may interact synergistically with aminoglycosides against gram-negative pathogens. Clinical study supports the usefulness of aztreonam against gram-negative nosocomial pneumonia. Since aztreonam is inactive against gram-positive and anaerobic bacteria, it must be used in combination with other antibiotics when these pathogens are suspected.
AuthorsJ L Cook
JournalThe American journal of medicine (Am J Med) Vol. 88 Issue 3C Pg. 34S-37S; discussion 38S-42S (Mar 23 1990) ISSN: 0002-9343 [Print] United States
PMID2316557 (Publication Type: Journal Article)
Chemical References
  • Aztreonam
Topics
  • Aztreonam (pharmacology, therapeutic use)
  • Bacterial Infections (drug therapy)
  • Cross Infection (drug therapy)
  • Gram-Negative Bacteria (drug effects)
  • Humans
  • Microbial Sensitivity Tests
  • Pneumonia (drug therapy)
  • Risk Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: