A therapeutic approach for female, relapsing genital lichen sclerosus: a single-center study.

Abstract

OBJECTIVE:

To assess the efficacy of methylprednisolone aceponate 0.1% (MPA 0.1%) in female genital lichen sclerosus (GLS) and efficacy of MPA, tacrolimus or emollient for prevention of flares.

METHODS:

A single-center, retrospective study was conducted. At baseline, female patients with relapsing GLS (n = 46) were treated with MPA 0.1% applied once daily for 8 weeks. Visual Analog Scale (VAS) score for vulvar pruritus and Investigator's Global Assessment (IGA) score were recorded at baseline, weeks 8 and 20. At week 8, patients responsive to treatment (n = 38) were further treated with MPA 0.1% twice weekly (n = 15), tacrolimus once daily (n = 13) or topical emollient once daily (n = 10), as maintenance therapy until week 20.

RESULT:

Both VAS and IGA median score was significantly decreased from baseline to week 8 (p = 0.000). At week 20, both median VAS and IGA scores differed significantly between patients treated with emollient and patients treated with MPA 0.1% (p = 0.000) and patients treated with emollient and patients treated with tacrolimus (p = 0.000); patients treated with MPA 0.1% presented no significant difference in either median VAS score (p = 0.032) or median IGA score (p = 0.636) at week 20 compared to patients treated with tacrolimus.

CONCLUSIONS:

MPA 0.1% is effective in relapsing female GLS. MPA 0.1% and tacrolimus have equal efficacy in preventing relapses.

• Authors: Aikaterini Patsatsi, Aikaterini Kyriakou, Dimitrios Vavilis, Athanasios Mantas, Christos Patsialas, Dimitrios Sotiriadis
• Journal: The Journal of dermatological treatment (J Dermatolog Treat) Vol. 24 Issue 5 Pg. 336-9 (Oct 2013) ISSN: 1471-1753 [Electronic] England
• PMID: 23164046 (Publication Type: Journal Article)

Chemical References

• Dermatologic Agents
• Emollients
• methylprednisolone aceponate
• Tacrolimus
• Methylprednisolone

Topics

• Aged
• Dermatologic Agents (administration & dosage)
• Emollients (administration & dosage)
• Female
• Humans
• Lichen Sclerosus et Atrophicus (drug therapy)
• Methylprednisolone (administration & dosage, analogs & derivatives)
• Middle Aged
• Retrospective Studies
• Secondary Prevention
• Tacrolimus (administration & dosage)
• Treatment Outcome