Abstract | OBJECTIVE: STUDY DESIGN: This study used MarketScan® claims data from January 1, 2003, to December 31, 2008. Male Medicare patients ≥ 65 years and Medicaid patients ≥ 50 years who received a diagnosis of BPH and at least one claim for a 5ARI during the study period were included. Cox proportional hazards models were used to evaluate the effect of length of therapy on AUR and surgery, whereas generalized linear models were used to assess the effect on costs. RESULTS: In 28,903 patients, every additional 30 days of 5ARI therapy reduced the likelihood of AUR and prostate surgery by 14 and 11%, respectively, while each 30-day increment of 5ARI therapy reduced BPH-related costs by 15%. CONCLUSION: For patients remaining on 5ARI therapy, significant clinical and economic benefits may be realized, including reductions in AUR and prostate surgery rates and reduced medical costs for these clinical events.
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Authors | Michael Eaddy, Eric Kruep, Orsolya Lunacsek, Bridget Goodwin |
Journal | Expert opinion on pharmacotherapy
(Expert Opin Pharmacother)
Vol. 13
Issue 18
Pg. 2593-600
(Dec 2012)
ISSN: 1744-7666 [Electronic] England |
PMID | 23163741
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 5-alpha Reductase Inhibitors
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Topics |
- 5-alpha Reductase Inhibitors
(administration & dosage, economics, therapeutic use)
- Aged
- Aged, 80 and over
- Cohort Studies
- Cost Savings
- Databases, Factual
- Follow-Up Studies
- Health Care Costs
- Humans
- Male
- Medicaid
- Medicare
- Medication Adherence
- Middle Aged
- Proportional Hazards Models
- Prostate
(drug effects, surgery)
- Prostatic Hyperplasia
(drug therapy, economics, physiopathology, surgery)
- Retrospective Studies
- United States
- Urinary Retention
(economics, etiology, prevention & control)
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