Platelet glycoprotein IaC807T polymorphisms and ischemic stroke in young Chinese Han population.

Abstract

OBJECTIVES:

The objective of this study was to investigate the association between platelet glycoprotein (GP) Ia C807T polymorphisms and ischemic stroke in young Chinese Han Population.

MATERIALS AND METHODS:

We conducted a case-control study in 92 consecutive young (</= 50 years) first-ever hospitalized ischemic stroke inpatients and outpatients, 86 elder ischemic stroke control (> 50 years), and 160 age- and sex-matched healthy control. Genotyping of platelet GP Ia C807Tpolymorphisms was performed by polymerase chain reaction followed by sequencing nucleic acid with dideoxy chain-termination method and an ABI PRISM3100 (Perkin-Elmer Co) genetic analyzer. Student's t-test, chi-square test, and logistic regression modeling were used for data significance analyses.

RESULTS:

Hypertension and smoking were found to be the independent risk factors for ischemic stroke patients (aged </= 50 years), while hypertension, diabetes and smoking were the independent risk factors for ischemic stroke patients (aged > 50 years). There was no significant difference observed in the T allele frequency of GPIa C807T polymorphisms between young stroke patients and corresponding controls.

CONCLUSIONS:

These findings suggest that there is no role of GPIa C807T polymorphisms in the development of young first-ever ischemic stroke in Chinese Han Population.

• Authors: J Zhang, D Huang, J Yang, H An, R Ojha, C DU, R Liu
• Journal: European review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci) Vol. 16 Issue 12 Pg. 1691-5 (Nov 2012) ISSN: 1128-3602 [Print] Italy
• PMID: 23161041 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Integrin alpha2

Topics

• Adult
• Age Factors
• Aged
• Asian People (genetics)
• Brain Ischemia (complications, genetics)
• Case-Control Studies
• Diabetes Complications (genetics)
• Female
• Gene Frequency (genetics)
• Genetic Predisposition to Disease (genetics)
• Humans
• Hypertension (complications, genetics)
• Integrin alpha2 (genetics)
• Male
• Polymorphism, Single Nucleotide
• Risk Factors
• Smoking (adverse effects, genetics)
• Stroke (complications, genetics)