Abstract | BACKGROUND: METHODS: The study included 35 patients who underwent unilateral adrenalectomy because of primary hyperaldosteronism after unequivocal successful lateralization by adrenal venous sampling. Demographics, biochemical evaluation, and blood pressure were assessed pre- and postoperatively. Pathology was categorized as APA (isolated adenoma), nodular (multiple micromacronodules), and diffuse UAH (gland thickening without nodules). RESULTS: Pathology revealed 9 APAs and 23 nodular and 3 diffuse UAHs. Patients with APAs and UAHs were statistically similar regarding demographics and preoperative blood pressure levels. Bilateral adrenal involvement was evident at imaging in 10 patients (11% in APA versus 35% in UAH, P = NS). After surgery, biochemical cure of the disease was achieved in all patients; blood pressure levels normalized in 66.6% of patients and ameliorated in 22.2% in APA versus 34.6% and 50% in patients with UAH (P = NS). At a long-term follow-up, only 1 patient with nodular UAH experienced a biochemical recurrence of disease. CONCLUSION: UAH is not rare, sharing the same features of APA. When disease lateralization is confirmed by adrenal venous sampling, unilateral adrenalectomy achieves excellent long-term results.
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Authors | Maurizio Iacobone, Marilisa Citton, Giovanni Viel, Riccardo Boetto, Italo Bonadio, Saveria Tropea, Franco Mantero, Gian Paolo Rossi, Ambrogio Fassina, Donato Nitti, Gennaro Favia |
Journal | Surgery
(Surgery)
Vol. 152
Issue 6
Pg. 1248-55
(Dec 2012)
ISSN: 1532-7361 [Electronic] United States |
PMID | 23158191
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Mosby, Inc. All rights reserved. |
Topics |
- Adrenal Cortex Neoplasms
(complications, diagnosis, surgery)
- Adrenal Glands
(pathology)
- Adrenalectomy
- Adrenocortical Adenoma
(complications, diagnosis, surgery)
- Adult
- Aged
- Female
- Humans
- Hyperaldosteronism
(diagnosis, etiology, surgery)
- Hyperplasia
- Male
- Middle Aged
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