[Similarity of cycloprolylglycine to piracetam in antihypoxic and neuroprotective effects].

Abstract

The antihypoxic activity of the endogenous cyclic dipeptide cycloprolylglycine (CPG) has been studied on a model of normobaric hypoxia with hypercapnia and its neuroprotective activity has been studied on a model of human neuroblastoma SH-SY5Y cell damage by 6-hydroxydopamine. It is established that CPG exhibits the antihypoxic activity at doses of 0.5 and 1.0 mg/kg (i.p.) on outbred and BALB/c mice, but not on C57B1/6 mice. The neuroprotective activity of CPG was detected in 10(-5) - 10(-8) M concentration range only when the treatment was carried out 24h before toxin introduction. The obtained data confirm the hypothesis that piracetam is a mimetic of the endogenous CPG neuropeptide.

• Authors: K N Kolisnikova, T A Gudasheva, G A Nazarova, T A Antipov, T A Voronina, S B Seredenin
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 75 Issue 9 Pg. 3-6 ( 2012) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 23156079 (Publication Type: Journal Article)

Chemical References

• Neuroprotective Agents
• Peptides, Cyclic
• Sympatholytics
• Oxidopamine
• cyclo(prolylglycyl)
• Piracetam

Topics

• Animals
• Cell Line, Tumor
• Dose-Response Relationship, Drug
• Humans
• Hypercapnia (chemically induced, prevention & control)
• Hypoxia (chemically induced, prevention & control)
• Mice
• Mice, Inbred BALB C
• Neuroprotective Agents (pharmacology)
• Oxidopamine (adverse effects, pharmacology)
• Peptides, Cyclic (pharmacology)
• Piracetam (pharmacology)
• Sympatholytics (adverse effects, pharmacology)