Photodynamic therapy using talaporfin sodium (Laserphyrin®) for bile duct carcinoma: a preliminary clinical trial.
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| Abstract |
The efficacy of adjuvant photodynamic therapy (PDT) using the new photosensitizer, talaporfin sodium (TPS), was assessed in 7 patients with bile duct carcinoma (BDC). The 664-nm semiconductor laser (100 J/cm(2)) was applied through endoscopy to the tumor lesion within 6 h after injection of TPS. Cases included three non-resectable and 4 resected BDC with remnant cancer cells at the bile duct stump. Radiated lesions exhibited mild inflammatory responses. Locally advanced tumor occluding bile duct was relieved by PDT and patency was maintained for 16 months. Two patients developed mild photodermatitis but no severe morbidity. One patient died of other disease, and two patients died of liver metastasis within 6 months, but local recurrence was not observed. Three patients maintained cancer-free survival for 6-13 months. One patient survived with good status for 24 months. Adjuvant TPS-PDT is a safe and useful treatment for local control of BDC. Compared to the conventional PDT, the patient's quality of life is remarkably improved.
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| Authors | Atsushi Nanashima, Takafumi Abo, Takashi Nonaka, Yoshikazu Nonaka, Tomohito Morisaki, Ryouhei Uehara, Ken Ohnita, Daisuke Fukuda, Goshi Murakami, Kazuo Tou, Masaki Kunizaki, Shigekazu Hidaka, Tomoshi Tsuchiya, Hiroaki Takeshita, Kazuhiko Nakao, Takeshi Nagayasu |
| Journal | Anticancer research (Anticancer Res) Vol. 32 Issue 11 Pg. 4931-8 (Nov 2012) ISSN: 1791-7530 [Electronic] Greece |
| PMID | 23155262 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't) |
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