Abstract | BACKGROUND: MATERIALS AND METHODS:
Tumor specificity index was determined by the ratio of the mean 50% cytotoxic concentration for normal cells to that for tumor cells. Apoptosis induction was monitored by internucleosomal DNA fragmentation and caspase-3, -8, and -9 activation. Fine cell structure was observed under transmission electron microscopy. RESULTS: CONCLUSION: These results suggest that midazolam may induce necrotic cell death, rather than apoptosis or autophagy, in OSCC cell lines.
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Authors | Seika Ohno, Katsue Kobayashi, Shigenori Uchida, Osamu Amano, Hiroshi Sakagami, Hiroshi Nagasaka |
Journal | Anticancer research
(Anticancer Res)
Vol. 32
Issue 11
Pg. 4737-47
(Nov 2012)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 23155237
(Publication Type: Journal Article)
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Chemical References |
- Anesthetics, Intravenous
- Thiamylal
- Thiopental
- Diazepam
- Midazolam
- Propofol
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Topics |
- Anesthetics, Intravenous
(toxicity)
- Carcinoma, Squamous Cell
(pathology, ultrastructure)
- Cell Death
(drug effects)
- Cell Line, Tumor
- DNA Fragmentation
(drug effects)
- Diazepam
(toxicity)
- Drug Screening Assays, Antitumor
- Humans
- Microscopy, Electron, Transmission
- Midazolam
(toxicity)
- Mouth Neoplasms
(pathology, ultrastructure)
- Necrosis
- Propofol
(toxicity)
- Thiamylal
(toxicity)
- Thiopental
(toxicity)
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