Abstract | OBJECTIVE: BACKGROUND: Some investigators have suggested that cholecystectomy increases the risk of intestinal cancer. Despite extensive study, the evidence remains inconclusive. If there is doubt about safety, the question arises of whether patients considering the operation should be told of a possible risk. It is also increasingly clear that there are noncausal associations between gallstones and intestinal cancer. METHOD: Analysis of record-linked hospital admission and mortality statistics for England from 1998 to 2008; calculation of ratio of rates of cancers in the cholecystectomy cohort and the gallbladder disease cohort compared with a control cohort. RESULTS: : In the first year after cholecystectomy, the rate ratios for cancer of the small intestine, colon, and rectum were significantly high at, respectively, 4.6 (95% confidence interval 3.9-5.5), 2.0 (1.9-2.1), and 1.7 (1.6-1.9). Rates of these cancers were also significantly high in people with gallstones without cholecystectomy. By 8 to 10 years after cholecystectomy, rate ratios had declined to nonsignificant levels. CONCLUSIONS:
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Authors | Michael J Goldacre, Clare J Wotton, Julie Abisgold, David G R Yeates, John Collins |
Journal | Annals of surgery
(Ann Surg)
Vol. 256
Issue 6
Pg. 1068-72
(Dec 2012)
ISSN: 1528-1140 [Electronic] United States |
PMID | 23154397
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Cholecystectomy
(adverse effects)
- Female
- Humans
- Intestinal Neoplasms
(epidemiology, etiology)
- Male
- Medical Record Linkage
- Middle Aged
- Young Adult
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