Abstract |
The discovery of the retinoblastoma (RB-1) gene as a tumor suppressor that is disrupted in a majority of human cancers either via direct or indirect genetic alterations has resulted in increased interest in its functions and downstream effectors. Although the canonical pathway that links this tumor suppressor to human cancers details its interaction with the E2F transcription factors and cell-cycle progression, recent studies have shown an essential role for RB-1 in the suppression of glycolytic and glutaminolytic metabolism. Characterization of the precise metabolic transporters and enzymes suppressed by the RB-E2F axis should enable the identification of small molecule antagonists that have selective and potent antitumor properties.
|
Authors | Brian F Clem, Jason Chesney |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 18
Issue 22
Pg. 6096-100
(Nov 15 2012)
ISSN: 1557-3265 [Electronic] United States |
PMID | 23154086
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Copyright | ©2012 AACR. |
Chemical References |
- Retinoblastoma Protein
- Glutamine
- Glucose
|
Topics |
- Animals
- Carbohydrate Metabolism
- Glucose
(metabolism)
- Glutamine
(metabolism)
- Humans
- Mitochondria
(metabolism)
- Molecular Targeted Therapy
- Neoplasms
(drug therapy, genetics, metabolism)
- Retinoblastoma Protein
(genetics, physiology)
|