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[Successful chemotherapy with a docetaxel regimen for primary signet-ring cell carcinoma of the urinary bladder-a case report].

Abstract
Primary signet-ring cell carcinoma of the bladder is rare and has a poor prognosis. In addition, there are few successful chemotherapies for it. We report a case of chemotherapy with a docetaxel regimen which was efficacious in a 64-year-old Japanese man suffering from the disease. The onset of bilateral hydronephrosis led to the detection of his bladder tumor, and its pathological diagnosis was signet-ring cell carcinoma(immunohistochemistry showed cytokeratin 7+/20±). He was treated with chemotherapy rather than with surgery because the tumor invaded the abdominal wall and groin. To treat his disease, we performed 2 courses of a chemotherapy regimen comprised of S-1 and cisplatin, but it was not efficacious. We chose docetaxel as a second-line chemotherapy regimen,(60mg/m2, tri-weekly), and a clinical examination including contrast-enhanced CT showed that his disease had successfully responded to the chemotherapy.
AuthorsKeita Tagami, Shigeru Tanda, Yohei Satake, Akira Takeuchi, Yuko Abe, Takashige Namima, Hiroaki Kusunose, Mitsuhisa Muto, Hiroshi Nagura
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 39 Issue 11 Pg. 1737-41 (Nov 2012) ISSN: 0385-0684 [Print] Japan
PMID23152031 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Antineoplastic Agents
  • Taxoids
  • Docetaxel
Topics
  • Antineoplastic Agents (therapeutic use)
  • Carcinoma, Signet Ring Cell (drug therapy, pathology, surgery)
  • Combined Modality Therapy
  • Docetaxel
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Taxoids (therapeutic use)
  • Tomography, X-Ray Computed
  • Urinary Bladder Neoplasms (drug therapy, pathology, surgery)

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