Synergistic effects of galantamine and memantine in attenuating scopolamine-induced amnesia in mice.

Abstract

We investigated a possible drug efficacy enhancement obtained by combining inactive doses of galantamine and memantine in the scopolamine-induced amnesia model in mice. We evaluated the effects of the two drugs, either alone or in combination, using the spontaneous alternation and object recognition tasks. In both tests, combination of low doses of galantamine (0.1 mg/kg, s.c.) and memantine (0.5 mg/kg, i.p.), which were sub-active per se, rescued the memory impairment induced by scopolamine (1 mg/kg, i.p.). The results suggest that combinations of galantamine and memantine might provide a more effective treatment of memory impairments in cognitive disorders than either drug used alone.

• Authors: Perrine Busquet, Valeria Capurro, Andrea Cavalli, Daniele Piomelli, Angelo Reggiani, Rosalia Bertorelli
• Journal: Journal of pharmacological sciences (J Pharmacol Sci) Vol. 120 Issue 4 Pg. 305-9 ( 2012) ISSN: 1347-8648 [Electronic] Japan
• PMID: 23149577 (Publication Type: Journal Article)

Chemical References

• Galantamine
• Scopolamine
• Memantine

Topics

• Amnesia (chemically induced, drug therapy, psychology)
• Animals
• Disease Models, Animal
• Drug Synergism
• Drug Therapy, Combination
• Galantamine (administration & dosage)
• Male
• Memantine (administration & dosage)
• Mice
• Mice, Inbred Strains
• Recognition, Psychology (drug effects)
• Scopolamine