Abstract | ETHNOPHARMACOLOGICAL RELEVANCE:
Indirubin, isolated from Indigo naturalis (Apiaceae) is a purple 3,2- bisindole and a stable isomer of indigo. Although it is known to have anti-inflammatory activities, its mechanism of action has not been elucidated. MATERIALS AND METHODS: RESULTS:
Indirubin treatment suppressed skin inflammation in DNCB-exposed mice. The skin lesions were significantly thinner in the Indirubin-treated group than in untreated controls, and the hyperkeratosis disappeared. Indirubin reduced the total serum IgE level and cytokines production. In addition, it normalized NF-κB, IκB-α and MAP kinase expression. CONCLUSIONS:
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Authors | Mi Hye Kim, You Yeon Choi, Gabsik Yang, Ik-Hyun Cho, Dongwoo Nam, Woong Mo Yang |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 145
Issue 1
Pg. 214-9
(Jan 09 2013)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 23149289
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents
- Cytokines
- Dinitrochlorobenzene
- I-kappa B Proteins
- Indoles
- NF-kappa B
- Immunoglobulin E
- Mitogen-Activated Protein Kinases
- indirubin
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology, therapeutic use)
- Cytokines
(metabolism)
- Dermatitis, Allergic Contact
(blood, drug therapy, pathology)
- Dinitrochlorobenzene
- Disease Models, Animal
- Female
- Hyperplasia
(chemically induced, pathology)
- I-kappa B Proteins
(metabolism)
- Immune System
(drug effects, metabolism)
- Immunoglobulin E
(metabolism)
- Indoles
(pharmacology, therapeutic use)
- Inflammation
(drug therapy, metabolism)
- Mice
- Mice, Inbred BALB C
- Mitogen-Activated Protein Kinases
(metabolism)
- NF-kappa B
(metabolism)
- T-Lymphocytes, Helper-Inducer
(drug effects, metabolism)
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