Abstract | INTRODUCTION: The chemoprevention refers to the use of various types of chemical agents for preventing carcinogenic progression. Systemic retinoids are the most studied chemopreventive agents due to their capacity to regulate cell proliferation and their demonstrated efficacy in several clinical studies. OBJECTIVES: METHODS: The authors reviewed the literature found through a search to MEDLINE (from 2001 to December 2011). RESULTS: CONCLUSION: Despite numerous studies of the literature concerning retinoids in chemoprevention of NMSC, precise details of the type of retinoid to use, dosage and the duration of this preventive treatment and how to manage side effects in the case of long-lasting treatment are still not uniform and comparable. Moreover, neither guidelines nor approval by Food and Drug Administration exist to regulate the use of retinoids in chemoprevention.
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Authors | Vincenzo Bettoli, Stefania Zauli, Anna Virgili |
Journal | The Journal of dermatological treatment
(J Dermatolog Treat)
Vol. 24
Issue 3
Pg. 235-7
(Jun 2013)
ISSN: 1471-1753 [Electronic] England |
PMID | 23148804
(Publication Type: Journal Article)
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Chemical References |
- Dermatologic Agents
- Isotretinoin
- Acitretin
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Topics |
- Acitretin
(adverse effects, pharmacology, therapeutic use)
- Basal Cell Nevus Syndrome
(drug therapy, prevention & control)
- Dermatologic Agents
(adverse effects, pharmacology, therapeutic use)
- Humans
- Isotretinoin
(adverse effects, pharmacology, therapeutic use)
- Off-Label Use
- Organ Transplantation
- Psoriasis
(complications)
- Risk Factors
- Skin Neoplasms
(chemically induced, drug therapy, prevention & control)
- Sunlight
(adverse effects)
- Xeroderma Pigmentosum
(drug therapy, prevention & control)
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