Clinical utility of serum reproductive hormones for the early diagnosis of ectopic pregnancy in the first trimester.

Abstract

AIM:

A tubal ectopic pregnancy (EP) in the first trimester remains a major life-threatening complication for the mother. We aim to determine whether serum reproductive hormones may be clinically useful in the early identification of a tubal EP.

METHODS:

A total of 109 age-matched patients with a serum β-human chorionic gonadotropin (β-hCG) concentration <2000 IU/L were enrolled, including 68 patients with a tubal EP, 22 with a viable intrauterine pregnancy (vIUP) and 19 with a non-viable intrauterine pregnancy (nIUP). Serum was collected during the first trimester of pregnancy and assayed for β-hCG, follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (TE), progesterone (P), estradiol (E₂) and prolactin (PRL) by using automated electrochemiluminescence immunoassays.

RESULTS:

Patients with an EP had significantly lower levels of daily β-hCG variation (Δβ-hCG/day), P and E₂, and significantly higher levels of LH and FSH than IUP patients (P<0.05). As an EP diagnostic marker, progesterone demonstrated a sensitivity of 100% at the cutoff of 86.01 nmol/L. The combination of E₂ with Δβ-hCG/day reached a specificity of 100% for EP evaluation. To identify non-viable pregnancies (including EPs and nIUPs), progesterone demonstrated a sensitivity of 95.40% and a specificity of 90.91% at the cutoff of 63.2 nmol/L; the diagnostic power of the receiver operating curve was 0.9702.

CONCLUSIONS:

A combination of Δβ-hCG/day, P and E₂ may help distinguish EPs and nIUPs from vIUPs, facilitating earlier diagnosis and the timely implementation of medical treatment to prevent tubal rupture.

• Authors: Chun Feng, Zheng-Yun Chen, Jing Zhang, Hong Xu, Xin-Mei Zhang, Xiu-Feng Huang
• Journal: The journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 39 Issue 2 Pg. 528-35 (Feb 2013) ISSN: 1447-0756 [Electronic] Australia
• PMID: 23148678 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology.

Chemical References

• Biomarkers
• Chorionic Gonadotropin, beta Subunit, Human
• Progesterone
• Estradiol
• Luteinizing Hormone
• Follicle Stimulating Hormone

Topics

• Biomarkers (blood)
• Chorionic Gonadotropin, beta Subunit, Human (blood)
• Early Diagnosis
• Estradiol (blood)
• Female
• Follicle Stimulating Hormone (blood)
• Humans
• Luteinizing Hormone (blood)
• Maternal Serum Screening Tests
• Pregnancy
• Pregnancy Trimester, First
• Pregnancy, Ectopic (blood, diagnosis)
• Pregnancy, Tubal (blood, diagnosis)
• Progesterone (blood)
• Retrospective Studies
• Sensitivity and Specificity