Abstract | OBJECTIVE: METHODS: RESULTS:
Neutrophil gelatinase-associated lipocalin, MIC-1, and CA19-9 were significantly elevated in the pancreatic juice of patients with CP and patients with PC as compared with nonpancreatic nonhealthy controls (P ≤ 0.034). Neutrophil gelatinase-associated lipocalin seemed most promising in differentiating diseased versus nondiseased pancreata (areas under the curve, 0.88-0.91), whereas MIC-1 was found to be higher in patients with PC than in patients with CP (P = 0.043). Interestingly, MIC-1 levels in diabetic patients with PC were higher than in nondiabetic patients with PC (P = 0.030) and diabetic patients with CP (P = 0.087). Carbohydrate antigen 19-9 showed the least ability to distinguish patient groups (areas under the curve, 0.61-0.76). CONCLUSIONS: Pancreatic juice neutrophil gelatinase-associated lipocalin shows potential utility in establishing pancreatic etiology in the context of nonspecific symptoms, whereas MIC-1 may aid in differentiating PC from CP.
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Authors | Sukhwinder Kaur, Michael J Baine, Sushovan Guha, Nobuo Ochi, Subhankar Chakraborty, Kavita Mallya, Colleen Thomas, Julia Crook, Michael B Wallace, Timothy A Woodward, Maneesh Jain, Shailender Singh, Aaron R Sasson, Verna Skinner, Massimo Raimondo, Surinder K Batra |
Journal | Pancreas
(Pancreas)
Vol. 42
Issue 3
Pg. 494-501
(Apr 2013)
ISSN: 1536-4828 [Electronic] United States |
PMID | 23146921
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acute-Phase Proteins
- Biomarkers
- CA-19-9 Antigen
- Growth Differentiation Factor 15
- LCN2 protein, human
- Lipocalin-2
- Lipocalins
- Proto-Oncogene Proteins
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Topics |
- Acute-Phase Proteins
(metabolism)
- Aged
- Biomarkers
(metabolism)
- CA-19-9 Antigen
(metabolism)
- Diabetes Mellitus, Type 2
(complications, metabolism)
- Diagnosis, Differential
- Enzyme-Linked Immunosorbent Assay
- Female
- Growth Differentiation Factor 15
(metabolism)
- Humans
- Lipocalin-2
- Lipocalins
(metabolism)
- Male
- Middle Aged
- Pancreas
(metabolism, pathology)
- Pancreatic Juice
(metabolism)
- Pancreatic Neoplasms
(complications, diagnosis, metabolism)
- Pancreatitis, Chronic
(complications, diagnosis, metabolism)
- Prospective Studies
- Proto-Oncogene Proteins
(metabolism)
- Radioimmunoassay
- Sensitivity and Specificity
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